Computational & Systems Biology
At the Lobo Lab we reverse engineer biological mechanisms with an integrated systems approach. We are interested in understanding, controlling, and designing the dynamic regulation and signaling that control living organisms. We develop new computational methods, create mathematical formalisms, and apply molecular assays to build mechanistic understanding of biology. We seek to discover the regulation of development and regeneration, find therapies for cancer and other diseases, and streamline the application of systems and synthetic biology.
We develop computational methods to automatically reverse engineer dynamic models, discover novel elements, and find the best next experiments to test.
We build quantitative mathematical models to understand, analyze, and predict the behavior of biological systems.
We create ontologies, curate databases, and develop expert systems used by both human scientists and artificial intelligence machines.
We study how shapes and patterns are formed from a single cell during development and restored through regeneration.
We seek to understand why and how regulatory mechanisms go awry to produce cancer and other diseases.
We design and optimize regulatory and metabolic networks with desired dynamics and behaviors to solve specific bioengineering problems.