Computational & Systems Biology
At the Lobo Lab we reverse engineer biological mechanisms. We are interested in understanding, controlling, and designing the dynamic regulation and signaling that direct complex biological processes. We develop new computational systems that can generate models, hypothesis, and theory from experimental data — automatically. We seek to discover the mechanisms of development and regeneration, find therapies for cancer and other diseases, and streamline the application of systems and synthetic biology.
We develop computational methods to automatically reverse engineer dynamic models, discover novel elements, and find the best next experiments to test.
We build quantitative mathematical models to understand, analyze, and predict the behavior of biological systems.
We create ontologies, curate databases, and develop expert systems used by both human scientists and artificial intelligence machines.
We study how shapes and patterns are formed from a single cell during development and restored through regeneration.
We seek to understand why and how regulatory mechanisms go awry to produce cancer and other diseases.
We design and optimize regulatory and metabolic networks with desired dynamics and behaviors to solve specific bioengineering problems.